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Reconstructing human skin in vitro consists of associating cells and natural or synthetic polymers in order to reproduce certain physiological functions of the epidermis and/or the dermis, the two principal layers of this organ. Since 1983, the year of the first epidermis reconstructed with a functional horny layer, different types of models have been perfected to reconstruct in vitro the structure of the epidermis alone, or the dermis alone or the whole dermo-epidermal unit.
Since 1989, L'Oréal has not tested any finished product on animals and reconstructed skin technology is a key element in keeping to this commitment:
- Evaluation of the safety and harmlessness of raw materials and finished products can be done using skin models. They also make it possible to screen new molecules by testing their efficacy.
- The models, reconstructed from normal human epidermal and/or dermal cells, are tools enabling fundamental research to acquire better understanding of the major functions of the skin.
- EPISKIN SNC standardises and produces on a large scale certain models which are use to evaluate the tolerance to products and in research to find new active substances. These objectives involve validate new alternative methods to animal testing.
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